Short-term effects of oral ketamine for the treatment of depression: A systematic review and meta-analysis of randomized controlled trials.
Asian J Psychiatr May 16, 2026 Sonia Shenoy, Vijetha Shenoy Belle, Ravindra Neelakanthappa Munoli et al. 1 citation
A systematic review and meta-analysis of randomized controlled trials found that oral ketamine produces short-term antidepressant effects. The analysis synthesizes evidence from multiple trials, indicating that oral ketamine can reduce depressive symptoms more than placebo or control conditions over brief follow-up periods. The review notes that the evidence base is still limited and that longer-term efficacy and safety require further investigation.