Changes in depression symptom network structure following ketamine treatment in treatment-resistant depression.
J Affect Disord May 14, 2026 Joshua Curtiss, Laya Dasari, Julianne Origlio et al.
Ketamine treatment alters the network structure of depression symptoms in people with treatment-resistant depression. The connections among symptoms, such as mood and sleep, shift after treatment, suggesting that ketamine may work by reorganizing how symptoms relate to one another rather than simply reducing overall severity.