Receptor interaction profiles of novel psychoactive tryptamines compared with classic hallucinogens.
Eur Neuropsychopharmacol May 20, 2016 Anna Rickli, Olivier D. Moning, Marius C. Hoener et al. 374 citations
Novel psychoactive tryptamines (DiPT, 4-OH-DiPT, 4-OH-MET, 5-MeO-AMT, and 5-MeO-MiPT) interact with serotonin 5-HT2A receptors as partial or full agonists, but with lower binding affinity than LSD. Their binding affinity correlates with reported psychoactive doses in humans. Several of these tryptamines, like psilocin and DMT, also interact with the serotonin transporter and partially with the norepinephrine transporter, similar to MDMA, whereas LSD does not. LSD, but not the tryptamines, interacts with adrenergic and dopaminergic receptors. The receptor interaction profiles suggest these tryptamines produce hallucinogenic effects similar to classic serotonergic hallucinogens along with MDMA-like psychoactive properties.