Pilot Results for Psilocybin-Assisted Psychotherapy for Cocaine Use Disorder-A Critical Appraisal.
JAMA Netw Open May 1, 2026 Erin E. Bonar
A critical appraisal of pilot results for psilocybin-assisted psychotherapy for cocaine use disorder, examining the initial findings and methodological limitations of early research in this area. The appraisal identifies significant challenges in study design, including small sample sizes and lack of adequate control conditions, which limit the reliability and generalizability of the reported outcomes. It emphasizes the need for more rigorous, larger-scale trials before drawing conclusions about efficacy. The analysis underscores the importance of cautious interpretation of pilot data and highlights specific methodological issues that must be addressed in future research to determine whether this treatment approach holds promise for cocaine use disorder.