Photolabeling of brain membrane proteins by lysergic acid diethylamide
Life Sciences April 5, 1982 Anne C. Mahon, Paul R. Hartig 7 citations
Under ultraviolet light, 3H-LSD forms an irreversible covalent bond with some proteins in bovine caudate membranes. The pattern of this photolabeling on gels differs from the general protein staining pattern, but it does not specifically target LSD binding sites linked to neurotransmitter receptors. Because photolabeling can also occur simply from prolonged exposure to room light, it may create artifacts in receptor binding assays.