Serotonin Receptor Binding Affinities of Several Hallucinogenic Phenylalkylamine and N,N-Dimethyltryptamine Analogues
Journal of Medicinal Chemistry January 1, 1978 Richard A. Glennon, Stephen M. Liebowitz, Elizabeth C. Mack 35 citations
Several hallucinogenic compounds related to phenylalkylamine and N,N-dimethyltryptamine bind to serotonin (5-HT) receptors in rat stomach tissue. The most behaviorally potent analogues tested—DOB, DOM, and 5-methoxy-N,N-dimethyltryptamine—showed high binding affinities, with pA2 values of 7.35, 7.12, and 7.08, respectively.