Decoupling of cortical activity from behavioral state following administration of the classic psychedelic DOI.
Neuropharmacology October 1, 2024 Randall J Olson, Lowell Bartlett, Alex Sonneborn et al. 3 citations
Classic psychedelics like DOI cause lasting changes in experience and show promise for treating depression. In the medial prefrontal cortex of male mice, DOI reduced low-frequency brain waves during rest, preventing the usual synchronization that occurs in less active states. It also increased gamma activity and suppressed fast-spiking neurons both during active and rest periods. These results suggest that DOI induces persistent desynchronization in the medial prefrontal cortex, which may contribute to the longer-lasting effects of psychedelics on brain plasticity and their therapeutic properties.