ASSAY OF LYSERGIC ACID DIETHYLAMIDE AND ITS PASSAGE FROM BLOOD INTO THE PERFUSED CEREBRAL VENTRICLES
British Journal of Pharmacology and Chemotherapy January 1, 1960 M. Draskoci 1 citation
Lysergic acid diethylamide (LSD) stimulates contractions in the isolated rat uterus at a concentration of 2×10⁻⁸. At lower concentrations (10⁻⁹ to 10⁻¹⁰), which do not themselves cause contractions, LSD enhances contractions induced by acetylcholine. This potentiating effect provides a method to measure tiny amounts of LSD. Using this assay in cats, during intravenous infusion of LSD at 10 μg/min/kg, between 0.4 and 2 ng/min of the substance entered the cerebral ventricles perfused with a fluid resembling cerebrospinal fluid.