Inverted U-Shaped Dose-Response Curve of the Anxiolytic Effect of Cannabidiol during Public Speaking in Real Life
Frontiers in Pharmacology May 11, 2017 Antônio Waldo Zuardi, Natália Pegoraro Rodrigues, Angélica L. Silva et al. 292 citations
Acute administration of 300 mg of cannabidiol (CBD) reduced subjective anxiety after a public speaking test in healthy adults, while 100 mg and 900 mg did not, confirming an inverted U-shaped dose-response curve similar to that seen in animal studies. Clonazepam (1 mg) also reduced anxiety but caused more sedation and smaller increases in blood pressure compared to CBD 300 mg. The public speaking test itself increased anxiety, heart rate, and blood pressure across all groups.