Signature of consciousness in brain-wide synchronization patterns of monkey and human fMRI signals
NeuroImage November 1, 2020 Gerald J. Hahn, Gorka Zamora‐lópez, Lynn Uhrig et al. 55 citations
Brain-wide signal levels can reliably distinguish sleep and anesthesia from the awake state in human and monkey fMRI resting state data. A whole-brain computational model reproduces changes in global synchronization, functional connectivity, structure-function relationship, integration, and segregation across vigilance states. The awake brain operates near a Hopf bifurcation, which coincides with globally correlated fMRI signals. Simulated lesions of connectivity hubs in the posterior brain and subcortical nuclei disrupt the model's awake state, matching predictions from graph-theoretical analyses of structural data.