Modeling Resting-State Functional Networks When the Cortex Falls Asleep: Local and Global Changes
Cerebral Cortex July 10, 2013 Gustavo Deco, P. Hagmann, Anthony G. Hudetz et al. 99 citations
The transition from wakefulness to sleep involves gradual neural changes rather than an abrupt shift. Local slow waves appear during wakefulness and increase as arousal-promoting neuromodulation decreases, while resting-state brain networks maintain their overall organization. Only when neuromodulation drops to very low levels do slow waves become global and resting-state networks merge into a single synchronized network.