Prevention and reversal of ketamine-induced schizophrenia related behavior by minocycline in mice: Possible involvement of antioxidant and nitrergic pathways
Journal of Psychopharmacology September 17, 2013 Aline Santos Monte, Greicy Coelho de Souza, Roger S. McIntyre et al. 123 citations
Minocycline, an antibiotic, prevented and reversed schizophrenia-like behaviors in mice given ketamine, including changes in movement, startle response, social interaction, and memory. It also corrected ketamine-induced oxidative stress—lowered glutathione and raised lipid peroxidation markers—and altered nitrite levels in the striatum. The effects were similar to those of the antipsychotic risperidone. The findings suggest minocycline's potential as a novel psychotropic agent, with its mechanism involving antioxidant and nitrergic systems.