Preliminary pharmacokinetic and psychophysical investigations after controlled oral and inhalative consumption of hexahydrocannabinol (HHC)
Scientific Reports March 24, 2025 Lisa Höfert, Benjamin Franz, Cedric Groß et al. 2 citations
After oral (25 mg fruit gum) or inhalative (three puffs from a vape) consumption of the semi-synthetic cannabinoid hexahydrocannabinol (HHC), its pharmacokinetics and psychoactive effects are comparable to those of tetrahydrocannabinol (THC). The route of administration and inter-individual factors strongly influence maximum concentrations, pharmacokinetic profiles, and the subjective 'high' feeling. Serum, urine, and saliva samples were analyzed for HHC and its metabolites. Three commercially available immunological tests were also evaluated for detectability.