Correlation of psychotomimetic activity of phenethylamines and amphetamines with 1-octanol-water partition coefficients
Journal of Medicinal Chemistry February 1, 1975 Charles F. Barfknecht, David E. Nichols, William J. Dunn 42 citations
The hallucinogenic potency of certain amphetamines and phenethylamines in humans may be related to their lipophilicity, as measured by the 1-octanol-water partition coefficient. For 11 amphetamines, these coefficients were measured directly, and for 17 additional amines they were estimated using published Hansch pi constants. The analysis suggests that an ideal log P value for psychotomimetic activity in humans may fall between 2.89 and 3.72.