Anhedonia in bipolar depression treated with ketamine
Bipolar Disorders February 4, 2024 Alina Wilkowska, Mariusz S. Wiglusz, Aleksandra Arciszewska et al. 17 citations
In patients with treatment-resistant bipolar depression, adding ketamine infusions to ongoing treatment reduced anhedonia, a debilitating symptom linked to suicidality and poor treatment response. Improvement was seen on both patient-reported and clinician-rated measures of anhedonia, and anxiety and mood/cognition symptoms also improved, but sleep symptoms did not. No serious adverse events occurred. The findings suggest ketamine may be a useful option for anhedonia in this population, though further research is needed.