A methoxydiphenidine-impaired driver
International Journal of Legal Medicine March 1, 2016 Nicole Stachel, Andrea Jacobsen-Bauer, Gisela Skopp
A case of driving under the influence of methoxydiphenidine (MXP) is reported, with a serum concentration of 57 ng/mL detected via liquid chromatography tandem mass spectrometry. The subject also had amphetamine (111 ng/mL), MDMA (28 ng/mL), and its metabolite (3 ng/mL) present. Symptoms included amnesia, out-of-body experiences, bizarre behavior, and decreased motor abilities. MXP is structurally and pharmacologically similar to phencyclidine and ketamine, acting at the NMDA receptor, suggesting it likely exerts severe psychotropic effects in humans. However, information on human toxicity, duration and intensity of impairing effects, interpretation of blood concentrations, and detectability in routine screenings is lacking. Confirmation analysis may be limited to cases with specific police intelligence.