John F Cryan

Department of Psychiatry and Neurobehavioral Science, University College Cork, Ireland.

2 papers in the library · 46 citations · publishing 2022-2023

Papers

Seeking the Psilocybiome: Psychedelics meet the microbiota-gut-brain axis.

International journal of clinical and health psychology : IJCHP January 1, 2023 John R Kelly, Gerard Clarke, Andrew Harkin et al. 33 citations

A systems psychiatry approach recognizes complex interactions across biological levels and requires integrated treatment strategies. Serotonergic psychedelics primarily target cortical 5-HT2A receptors, but their therapeutic mechanisms span molecular, cellular, and network levels, influenced by biofeedback from the periphery and environment. The gut microbiome, through the gut-brain axis, regulates host neurophysiology via unconscious parallel processing systems. Although psychedelic and microbial signaling operate on different timescales, the microbiota-gut-brain axis may contribute to the preparatory, acute, and integration phases of psychedelic therapy. This review examines the gut microbiome and mycobiome, pathways of the MGB axis, and potential interactions with psychedelic therapy, discussing implications for precision medicine.

DOI: 10.1016/j.ijchp.2022.100349 Full text Psilocybin LSD Dimethyltryptamine DMT Microbiota-gut-brain axis +7

The 4E approach to the human microbiome: Nested interactions between the gut-brain/body system within natural and built environments.

BioEssays : news and reviews in molecular, cellular and developmental biology June 1, 2022 Ismael Palacios-García, Gwynne A Mhuireach, Aitana Grasso-Cladera et al. 13 citations

Human cognition depends not only on brain processes but also on bodily and environmental factors, a view known as the 4E perspective (embodied, embedded, enacted, extended). The human microbiome—the community of microorganisms living in and on the body—is a key mediator of this interaction, influencing brain function and mental health across a person's lifetime. This theoretical review presents a 4E approach to the microbiome, arguing that microbial networks from the gut, skin, and built environments shape mental processes. The authors review evidence for this framework and outline future research and clinical interventions that integrate biological, psychological, social, and environmental factors, particularly targeting the brain-gut-microbiome axis for low-cost, personalized mental health treatments.

DOI: 10.1002/bies.202100249 Full text 4e cognition Built environment Gut-brain axis Mental health +1