Psychedelics and reconsolidation of traumatic and appetitive maladaptive memories: focus on cannabinoids and ketamine.
Psychopharmacology February 1, 2018 Liana Fattore, Alessandro Piva, Mary Tresa Zanda et al.
A review of preclinical and clinical data examines whether cannabinoids and ketamine can modulate the reconsolidation of maladaptive memories, a process that may underlie their potential therapeutic use in post-traumatic stress disorder and substance use disorders. The authors propose that memory reconsolidation modulation is a hypothetical process explaining the efficacy of these substances, and they report findings that support or do not support this working hypothesis. Metaplasticity is suggested as a common process mediating the effects of cannabinoids and ketamine on maladaptive memories.