Inflammatory state moderates response to cannabis on negative affect and sleep quality in individuals with anxiety
Frontiers in Behavioral Neuroscience July 1, 2025 Richard G. Hunter, Annelise Madison, Jonathon K. Lisano et al.
In people with anxiety, baseline inflammatory status moderates how cannabis use affects negative affect and sleep quality. Over four weeks, participants with mild or greater anxiety who used cannabis chemovars higher in cannabidiol (CBD) showed more consistent improvements in mood and sleep, whereas improvements with delta-9-tetrahydrocannabinol (THC)-dominant chemovars varied depending on the individual's baseline inflammation. No group-dependent changes in cytokine concentrations were observed over the study period.