Genetic dissection of the psychotomimetic effects of cannabinoid exposure.
Progress in neuro-psychopharmacology & biological psychiatry July 3, 2014 Colm M P O'Tuathaigh, Ilse Gantois, John L Waddington
Cannabis use increases the risk of developing schizophrenia and related psychotic disorders. Factors such as age at first cannabis use, genetic predisposition, and other environmental risks may influence susceptibility. Genetic studies increasingly implicate genes involved in dopamine signaling in the link between cannabis and psychosis. This review examines human and animal research on the neural basis of these interactions. More studies are needed to understand the long-term and neurodevelopmental effects of cannabis use, which could clarify the cannabis-psychosis relationship.