Cannabis Use and the Risk for Psychosis and Affective Disorders
Journal of dual diagnosis January 2, 2020 L. Sideli, H. Quigley, C. la Cascia et al.
Heavy use of high-potency cannabis that is high in THC and low in CBD increases the risk of psychotic disorders, with greater risk for early use and use of synthetic cannabinoids. Frequent cannabis use also raises the risk for mania and suicide, but the effect on depression is less clear and findings on anxiety are contradictory. Depression and anxiety may lead to greater cannabis consumption in some studies. THC interacts with genetic predisposition and other environmental factors, while CBD may reduce the psychotogenic effects of THC but is absent from many high-potency varieties. The evidence is strong enough to merit public health education about psychosis risk.