Influence of solvent, sex, and age on pharmacokinetic and acute behavioral effects of vaporized cannabis extract in mice
S.R. Westbrook, A.L. Jensen, V. Copeland-Solorzano et al. preprint
Vaporized cannabis extract dissolved in polyethylene glycol 400 (PEG) produces higher plasma THC levels and stronger behavioral effects than when dissolved in propylene glycol/vegetable glycerol. In mice, the highest dose (300 mg/ml) caused reduced body temperature, pain sensitivity, and movement. Adolescent mice were less sensitive to the movement-suppressing effects than adults, and female mice metabolized THC more slowly than males, though no sex differences in acute behavioral effects were observed.