Individual differences in the pharmacokinetic profiling of Δ9-THC may be associated with differential motivational effects of Δ9-THC on cognitive performance
Teneisha M. Myers, Noah C. Neverette, Aaron S. Devanathan et al. preprint
Acute restraint stress and THC did not impair working memory in rats. However, a 3 mg/kg dose of THC disrupted motivation-related task engagement in some rats, while others were unaffected. Those that stopped responding had higher plasma THC and metabolite concentrations than those that continued. Individual differences in THC metabolism may explain why some people experience adverse cognitive or motivational effects after cannabis use, while others do not.