Screening of 104 New Psychoactive Substances (NPS) and Other Drugs of Abuse in Oral Fluid by LC-MS-MS.
Journal of analytical toxicology October 12, 2020 Kelly Francisco da Cunha, Karina Diniz Oliveira, Marilyn A Huestis et al. 73 citations
A new LC-MS-MS method can detect 104 drugs of abuse, including synthetic cannabinoids, cathinones, fentanyl analogues, and other psychoactive compounds, in oral fluid samples collected with a Quantisal™ device. The method uses a 13.5-minute run and achieves limits of detection as low as 0.05 ng/mL for most analytes, though some require higher concentrations. Matrix effects are generally around 60%, and recoveries range from 47.2% to 127%. Drug stability is best at -20°C, but even frozen, some synthetic cannabinoids degrade more than 20% over 90 days. The method was successfully tested on seven authentic samples, confirming 17 different analytes.