Subjective and psychomotor effects of bolus doses of nitrous oxide in humans
Human Psychopharmacology: Clinical and Experimental March 1, 1993 Cathleen S. Dohrn, J. Lance Lichtor, Dennis W. Coalson et al.
Inhaling a brief, high-concentration bolus of nitrous oxide produces short-lived subjective effects including increased ratings of 'high,' 'tingling,' 'stimulated,' and 'confused,' along with greater euphoria and psychedelic-like effects, especially at 40% and 80% concentrations. These effects typically dissipated within minutes. Psychomotor performance measured 2.5 minutes after inhalation did not differ from baseline, though the timing of measurement may have missed peak effects. The findings align with the recreational appeal of nitrous oxide.