Alterations in temporal-spatial brain entropy in treatment-resistant depression treated with nitrous oxide: Evidence from resting-state EEG.
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology March 1, 2025 Weizhuang Kong, Zhe Sun, Jing Zhu et al.
Nitrous oxide inhalation produced time-dependent increases in brain entropy, particularly in the frontal lobe, among patients with treatment-resistant depression. These entropy changes, measured via multivariate multiscale entropy analysis of resting-state EEG, correlated with symptom severity and treatment efficacy, suggesting frontal region temporal-spatial brain entropy may serve as a biomarker for treatment-resistant depression and its treatment outcomes.