Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
May 1, 2025
Paolo Cardone, Pablo Núñez, Naji L N Alnagger et al.
7 citations
A patient in a minimally conscious state plus received psilocybin, a classic psychedelic, for the first time. No increase in overt behavioral repertoire was observed on validated scales, but new spontaneous behavior not previously seen emerged, and brain complexity, measured by the Lempel-Ziv complexity index, increased with changes in underlying periodic rhythms. This case report contributes to future investigations of psychedelics for disorders of consciousness and the link between brain complexity and consciousness.
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
May 1, 2025
Cecilia Catania, Marco Mancuso, Adolfo Mazzeo et al.
3 citations
In people with psychogenic non-epileptic seizures (PNES), a type of dissociative event, brain activity patterns shift markedly during the events compared to resting periods. EEG microstate analysis of 22 PNES patients and 24 healthy controls showed that microstate C, linked to the default mode network, was more prominent at rest in patients than in controls, but its duration, coverage, and global field power all decreased significantly during PNES events. This suggests a major change in default mode network dynamics during dissociative events, pointing to a mix of pathological and adaptive brain processes underlying PNES.
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
March 1, 2025
Weizhuang Kong, Zhe Sun, Jing Zhu et al.
Nitrous oxide inhalation produced time-dependent increases in brain entropy, particularly in the frontal lobe, among patients with treatment-resistant depression. These entropy changes, measured via multivariate multiscale entropy analysis of resting-state EEG, correlated with symptom severity and treatment efficacy, suggesting frontal region temporal-spatial brain entropy may serve as a biomarker for treatment-resistant depression and its treatment outcomes.
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
February 1, 2013
Brett L Foster, David T J Liley
Nitrous oxide reduces resting total brain wave power, especially delta waves at frontal-vertex sites, in healthy men. After inhalation stops, frontal theta power increases above baseline. Unlike other anesthetics such as propofol and sevoflurane, nitrous oxide does not shift slow wave activity to the front of the brain, challenging a single mechanism for loss of consciousness based on EEG patterns.