Sex differences in psychotomimetic-induced behaviours in rats.
Behavioural brain research March 30, 2017 Andrea Gogos, Snezana Kusljic, Shane J Thwaites et al.
Acute amphetamine caused greater distance traveled (locomotor hyperactivity) in female rats than in male rats, while phencyclidine-induced locomotor hyperactivity was similar in both sexes. No sex differences were observed in amphetamine- or phencyclidine-induced disruption of prepulse inhibition. Male rats showed an increased startle response after amphetamine. These findings suggest that sensitivity to amphetamine, but not phencyclidine, differs between male and female rats, and this sex difference is selective to locomotor hyperactivity and startle, not prepulse inhibition.