Mouse strain differences in phencyclidine-induced behavioural changes.
The international journal of neuropsychopharmacology July 1, 2012 Akihiro Mouri, Takenao Koseki, Shiho Narusawa et al.
Different mouse strains show distinct behavioral responses to the psychosis-inducing drug phencyclidine (PCP). C57BL/6N, C57BL/6J, ddY, and ICR mice were compared. PCP caused greater hyperactivity and increased immobility in the forced swim test in ddY mice than in C57BL/6N and C57BL/6J, with ICR mice showing the least effect. However, no strain differences appeared in recognition memory impairment after chronic PCP withdrawal. These findings offer practical guidance for comparing genetic and drug-induced psychosis models in the C57BL/6 strain, which is commonly used in genetic studies, and suggest that strain differences may help identify biological mechanisms underlying PCP-induced behaviors relevant to major mental illnesses.