Selective potentiation of the metabotropic glutamate receptor subtype 2 blocks phencyclidine-induced hyperlocomotion and brain activation.
Neuroscience June 16, 2010 E A Hackler, N E Byun, C K Jones et al.
In rats, the compound BINA, which potentiates the mGluR2 receptor, reduced hyperactivity and brain activation caused by the NMDA antagonist PCP, a model of schizophrenia symptoms. BINA suppressed PCP-induced blood oxygenation level-dependent (BOLD) signals in the prefrontal cortex, caudate-putamen, nucleus accumbens, and mediodorsal thalamus. These findings support mGluR2 as a viable target for schizophrenia treatment.