Behavioral effects of ketamine, an NMDA glutamatergic antagonist, in non-human primates.
Psychopharmacology September 1, 1999 Y Shiigi, D E Casey
Ketamine, a drug that blocks NMDA receptors, produced dose-related increases in parkinsonian symptoms (bradykinesia and dystonia) and salivation, along with decreases in locomotor activity and reactivity to environmental stimuli in Cebus monkeys. These effects had short time courses and steep dose-response curves. The findings suggest that ketamine-induced behavioral changes in non-human primates can serve as a model for studying the role of glutamate systems in motor and mental functions such as attention or perception.