The behavioral and neurochemical effects of phencyclidine in humans and animals: some implications for modeling psychosis.
Behavioural brain research January 1, 1996 R E Steinpreis
Phencyclidine (PCP) produces a psychotic reaction in humans that closely resembles an acute episode of schizophrenia, making it a valuable model for the disorder. This review examines the behavioral and neurochemical effects of PCP in both humans and animals, comparing them with those of amphetamine where possible. It discusses the roles of dopamine and NMDA/PCP receptors in mediating PCP-induced psychosis and emphasizes the importance of selecting behavioral models that capture the expression of psychosis rather than just the motor effects of psychotomimetic drugs.