NE-100, a novel sigma receptor ligand: effect on phencyclidine-induced behaviors in rats, dogs and monkeys.
Life sciences January 1, 1994 S Okuyama, Y Imagawa, T Sakagawa et al.
NE-100, a drug being considered for schizophrenia, had no effect on conditioned avoidance responses in rats but attenuated PCP-induced impairment of avoidance inhibition. In rhesus monkeys, NE-100 partially overcame PCP-induced ataxia or decreased attention. In dogs, NE-100 blocked PCP-induced head-weaving behavior or ataxia. PCP increased beta-2 and decreased delta relative power in cortical ECoG activity in dogs; NE-100 alone showed no significant change in these measures but blocked the PCP-induced beta-2 increase and delta decrease. These findings indicate that NE-100 attenuates the effects of PCP in experimental animals.