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S Otomo

2 papers in the library · publishing 1994

Papers

NE-100, a novel sigma receptor ligand: effect on phencyclidine-induced behaviors in rats, dogs and monkeys.

Life sciences January 1, 1994 S Okuyama, Y Imagawa, T Sakagawa et al.

NE-100, a drug being considered for schizophrenia, had no effect on conditioned avoidance responses in rats but attenuated PCP-induced impairment of avoidance inhibition. In rhesus monkeys, NE-100 partially overcame PCP-induced ataxia or decreased attention. In dogs, NE-100 blocked PCP-induced head-weaving behavior or ataxia. PCP increased beta-2 and decreased delta relative power in cortical ECoG activity in dogs; NE-100 alone showed no significant change in these measures but blocked the PCP-induced beta-2 increase and delta decrease. These findings indicate that NE-100 attenuates the effects of PCP in experimental animals.

DOI: 10.1016/0024-3205(94)00749-7 Full text

A rat model of phencyclidine psychosis.

Life sciences January 1, 1994 S Ogawa, S Okuyama, H Araki et al.

Rats given low doses of phencyclidine (PCP) showed impaired performance in water maze and diving tasks: their swimming latencies shortened gradually while diving latencies increased, whereas control rats performed well. No stereotyped behavior or hyperlocomotion was observed. The authors propose that this animal model, using lower PCP doses, may be useful for studying schizophrenia.

DOI: 10.1016/0024-3205(94)00326-2 Full text