Alterations in local cerebral glucose utilization induced by phencyclidine.
Brain research December 1, 1987 A D Weissman, M Dam, E D London
Phencyclidine (PCP) at doses of 0.5 to 10 mg/kg intravenously altered glucose use in 41 of 87 brain regions of rats, with changes ranging from 25% to 270% of control levels. Glucose metabolism increased throughout the limbic system except the habenula, increased in most sensory structures but decreased in specific layers of the somatosensory and auditory cortices and the inferior colliculus, and increased throughout the motor system with a striking columnar pattern in the motor cortex while decreasing in the frontal cortical pole. Effects of 5 mg/kg diminished over time, though eight regions maintained altered metabolism at 180 minutes. The findings suggest PCP activates functional circuits, especially the limbic system, which may underlie its psychotomimetic properties.