Action of hallucinogens on raphe-evoked dorsal root potentials (DRPs) in the cat.
Pharmacology, biochemistry, and behavior February 1, 1986 A A Larson, E G Anderson
A single low dose of LSD potentiates the dorsal root potential (DRP) evoked by stimulation of the inferior central nucleus in cats, whereas 5-MeODMT, ketamine, and PCP inhibit it. Tolerance develops to LSD's facilitatory effect but not to 5-MeODMT's inhibition, and ketamine's effect does not produce tachyphylaxis. The raphe-evoked DRP, traditionally thought to be serotonin-mediated, may actually involve a non-serotonergic transmitter, as tryptophan and fluoxetine do not potentiate it, and it resists blockade by serotonin-depleting agents.