Variability in outcomes and subjective effects of psychedelic use in psychotic populations: Case-based evidence from naturalistic settings
Psychedelics May 14, 2026 Joseph la Torre, Jade Gallo, Matteo Buonaroti et al.
People with histories of psychotic symptoms who used psychedelics in naturalistic settings reported both benefits and harms. Benefits included personal growth, insight, increased spirituality, and symptom reappraisal. Challenging experiences and adverse effects also occurred, especially when set and setting were unfavorable. The findings question the categorical exclusion of this population from psychedelic research and therapy, and call for more holistic, ethically guided study of psychedelic-assisted therapy for this underserved group.