Classical psychedelics like LSD, psilocybin, and ayahuasca consistently disrupt resting-state connectivity within the Default Mode Network (DMN) and increase functional connectivity between canonical resting-state networks. The DMN, a set of brain regions active during self-referencing and mind wandering, is altered in various neuropsychiatric conditions. While DMN modulation is central to some cognitive models of psychedelics, its role in their therapeutic potential remains unclear. This systematic review provides a comprehensive overview to guide future research on the neurocognitive mechanisms of these agents.
Hallucinations and delusions are common in borderline personality disorder (BPD) and often resemble those in schizophrenia spectrum disorders. In a study of 89 adults, 81% of those with BPD reported visual and tactile hallucinations, 75% reported olfactory hallucinations, and 94% experienced delusions. Comparing BPD with and without voices showed no significant differences in nonpsychotic psychopathology. Hallucinations in BPD were similar to those in schizophrenia, though the BPD group had higher rates of paranoia and delusions of guilt. Multisensory hallucinations and delusions in BPD warrant clinical attention.