3D Microfluidic Channel Development for a Microdosing System
Ana C. Romo-Cardenas, Carlos A. Ruiz-Delgado, Paulo C. Calvo et al. preprint
A passively operated microfluidic device fabricated using 3D-printed templates enables insulin microdosing. The system includes a microvalve with a spiral trajectory and four outlet channels that align with a 10 mm x 15 mm matrix of 25 microchannels, each 770 µm in internal diameter. It delivers a dose of 2.3 mL in 6 minutes. The design enhances fluid dynamics without affecting insulin stability and allows the use of Humalog insulin in tropical climates up to 30°C without refrigeration for 28 days. The approach can be adapted for microdosing other drugs.