Hallucinogen use in the United States has shifted in opposite directions across age groups since 2002. Among adolescents aged 12–17, use declined, while adults aged 26 and older showed increased use, particularly after 2015. By 2019, over 5.5 million adults aged 18 and older were estimated to have used hallucinogens in the past year. Lysergic acid diethylamide (LSD) use rose across all age groups, while ecstasy use fell among adolescents and adults. Phencyclidine (PCP) use decreased overall and among younger age groups. These trends come from nationally representative survey data spanning 2002 to 2019.
Lifetime use of psilocybin, tryptamine, and ketamine increased among U.S. adults from 2002 to 2019, while mescaline use declined. Among people aged 26 and older, use of most plant-based hallucinogens and dissociative agents rose, but adolescents and young adults showed decreases. Overall, use of these substances remains rare. The findings are based on nationally representative data from over one million respondents aged 12 and older.