Repeated Exposure to the “Spice” Cannabinoid JWH-018 Induces Tolerance and Enhances Responsiveness to 5-HT1A Receptor Stimulation in Male Rats
Frontiers in Psychiatry February 27, 2018 Joshua S. Elmore, Michael H. Baumann 26 citations
Repeated exposure to the synthetic cannabinoid JWH-018, found in psychoactive 'spice' products, produces tolerance to its own hypothermic and cataleptic effects in male rats, and transiently enhances sensitivity of 5-HT1A receptors, as shown by augmented behavioral and hypothermic responses to the 5-HT1A agonist 8-OH-DPAT one day after treatment cessation. However, it does not affect behaviors induced by the 5-HT2A/2C receptor agonist DOI.