A Meta-Analysis of fMRI Activation Studies of Ketamine in Healthy Participants
European Psychiatry April 1, 2024 J. H. Shepherd, A. Hickman, C.t.m. Baten et al.
Acute ketamine administration alters neural activation in multiple cortical and subcortical regions in healthy people, as shown by a meta-analysis of 18 fMRI studies with 306 participants. The analysis used multilevel kernel density analysis and ensemble thresholding to minimize bias. These findings help map the functional neuroanatomical effects of ketamine, which may inform its therapeutic use for psychiatric and neurological conditions. Future research should examine both short- and long-term neural effects in clinical populations.