Frontiers in Human Neuroscience
January 1, 2013
Catherine E. Kerr, Matthew D. Sacchet, Sara W. Lazar et al.
329 citations
Standardized mindfulness practices that focus attention on breath and body sensations may work by training the brain to better regulate alpha rhythms (7-14 Hz) in the primary somatosensory cortex. These alpha rhythms filter sensory information entering the neocortex. The framework suggests that in chronic pain, somatic attention in mindfulness reduces pain-focused attentional resources by altering alpha activity. In depression relapse prevention, somatic attention competes with rumination, as internal cognitive processes rely on alpha filtering. A computational model predicts enhanced top-down modulation of alpha through precise timing changes in thalamocortical inputs. The theory aligns with Buddhist teachings that mindfulness begins with mindfulness of the body, proposing that enhanced alpha regulation improves detection and regulation of mind-wandering.
Neurosci Biobehav Rev
February 22, 2022
Idil Sezer, Diego A. Pizzagalli, Matthew D. Sacchet
206 citations
This review synthesizes evidence on the relationship between resting-state fMRI functional connectivity and mindfulness in both clinical and non-clinical populations. The authors find that mindfulness practice is associated with altered functional connectivity in brain networks involved in attention, self-referential processing, and emotion regulation. These changes may underlie the psychological benefits of mindfulness, but the review notes that the current evidence is mixed and limited by heterogeneous methodologies and small sample sizes.
Mindfulness
April 13, 2023
Julieta Galante, Andrea Grabovac, Malcolm Wright et al.
82 citations
About half of the millions of people who learn mindfulness meditation continue regular practice after initial instruction, but it is unclear whether benefits increase with ongoing practice or whether harm can occur. Evidence shows a wide range of experiences from positive to challenging and potentially harmful. Complex interactions and temporal sequences may explain these experiences and their links to health and well-being. Effects may vary systematically due to factors like initial dosage, accumulated practice, developing skill, and interactions with past experiences and environment. The authors call for interdisciplinary, ontologically agnostic research using longitudinal models and insights from contemplative traditions to develop safer, more effective applications.
Neuropsychologia
September 28, 2023
Avijit Chowdhury, Remko Van Lutterveld, Ruben E. Laukkonen et al.
54 citations
In a single intensively sampled case, EEG spectral analysis was used to investigate advanced mindfulness meditation "cessation" experiences, revealing distinct neural signatures associated with these profound meditative states.
World Psychiatry
June 1, 2024
Matthew D. Sacchet, Maurizio Fava, Eric L. Garland
35 citations
Meditation and psychedelics both appear to alter self-referential processing, potentially leading to experiences of self-transcendence. This review examines whether scientific investigation of self-transcendence through these methods has clinical relevance. The authors suggest that changes in self-referential processing may underlie therapeutic benefits for mental health conditions, though the exact mechanisms remain unclear. The paper argues that understanding how meditation and psychedelics modulate the sense of self could inform new treatments for disorders characterized by maladaptive self-focus, such as depression and anxiety.
Heliyon
May 14, 2024
Winson F.z. Yang, Terje Sparby, Malcolm Wright et al.
30 citations
Advanced concentrative absorption meditation, such as the jhanas, involves volitional mental absorption that can be scientifically studied. This paper argues that these states represent a distinct category of meditative experience characterized by deep, effortless focus and profound well-being. It proposes a scientific framework for understanding these measurable states of consciousness, drawing on existing research to outline how absorption, concentration, and positive outcomes like well-being can be systematically investigated. The authors suggest that developing a rigorous scientific approach to jhana and similar practices could bridge contemplative traditions and consciousness research, offering new insights into the nature of deep meditative states and their potential benefits.
Cerebral Cortex
December 16, 2019
Danielle D. DeSouza, Katy H. Stimpson, Laima Baltusis et al.
26 citations
Hypnotizability, a stable trait in adulthood, is linked to the concentration of the neurotransmitter GABA in the anterior cingulate cortex (ACC). In healthy individuals, higher ACC GABA levels were positively associated with higher hypnotizability scores measured by the Hypnotic Induction Profile. An exploratory analysis also found a negative relationship between glutamate levels and the absorption and imaginative involvement subscale of the Dissociative Experiences Scale. These findings suggest a neurobiological basis for individual differences in hypnotic responsiveness, which may help explain variability in treatment outcomes for hypnosis-based psychotherapies.
Neuroimage
December 14, 2024
Avijit Chowdhury, Marta Bianciardi, Eric Chapdelaine et al.
14 citations
Advanced meditation states known as Jhanas, achieved through concentration absorption, are associated with distinct patterns of brain activity and subjective experience. In an intensive case study of an experienced meditator, each Jhana state showed unique neural signatures, including changes in gamma power, alpha desynchronization, and connectivity between frontal and parietal regions. These findings suggest that Jhana states are not merely variations of ordinary mindfulness but involve specific, reproducible neurophenomenological profiles. The work demonstrates that deep meditative absorption can be systematically studied using multimodal brain imaging and first-person reports, providing a foundation for understanding altered states of consciousness.
Imaging Neuroscience
January 1, 2025
Jonathan M. Lieberman, Patrick A. McConnell, Mar Estarellas et al.
9 citations
Focused attention meditation (FA) involves concentrating on a specific object, like the breath, while letting go of distractions. This scoping systematic review examined EEG and MEG studies on FA to clarify how these studies are designed and what they found about brain activity. The review found that participant characteristics varied widely across studies, which may explain inconsistent results, while the types of meditation tasks and control conditions used were fairly similar. Consistent neurophysiological trends show that FA is linked to increased brainwave power in alpha, beta, and gamma bands, along with higher neural complexity and reduced criticality. The review recommends methodological improvements and notes gaps, such as limited MEG use and a lack of longitudinal studies.
January 31, 2024
Joshua Cain, Tracy Brandmeyer, Ninette Simonian et al.
9 citations
preprint
Focused ultrasound stimulation of the caudate nucleus significantly improves self-reported meditative depth and mood in experienced vipassana meditators, and is accompanied by reduced heart rate and increased heart rate variability. These physiological changes strongly correlate with reported depth, suggesting a mechanistic link between reduced arousal and successful meditation. Stimulation of the posterior cingulate cortex or insula did not produce similar effects. The findings indicate that targeted neuromodulation may help lower the barrier to consistent meditation practice for novice or intermediate meditators.
October 19, 2023
Leonardo Christov‐moore, Félix Schoeller, Caite Lynch et al.
6 citations
preprint
Aesthetic chills—the pleasurable, cold sensation often experienced during music or film—are robustly linked to self-transcendence, a positive altered state involving ego-dissolution, connectedness, and moral elevation. In 2,937 participants exposed to chills-eliciting stimuli, chills occurrence and intensity formed a tightly interrelated construct with measures of self-transcendence, even after controlling for prior state and trait differences. The findings suggest that self-transcendence experiences can be reliably evoked through exposure to audiovisual media that elicit chills, offering a more accessible path to study and apply self-transcendence for well-being and prosociality compared to conventional methods like meditation or psychedelics.
bioRxiv Preprint Server
September 6, 2025
Winson F.z. Yang, Akila Kadambi, Kilian Abellaneda-Pérez et al.
4 citations
preprint
An advanced meditative state called extended cessation (EC), where consciousness is voluntarily suspended and later resumes with heightened clarity and equanimity, provides a natural model for studying consciousness. Using ultra-high-resolution 7T fMRI with dense sampling of three individuals, the research mapped whole-brain activity, connectivity, gradients, and eigenmodes during EC, linking them to brain chemistry and cognitive maps. EC increased activity in sensory regions, reduced activity in higher-order association areas, subcortex, and brainstem, expanded the principal cortical gradient, and decreased low-order global eigenmodes.
bioRxiv (Cold Spring Harbor Laboratory)
Ruby M. Potash, Sean D. Van Mil, Mar Estarellas et al.
4 citations
preprint
During a deep meditative state called jhana, the brain's non-oscillatory, nonlinear neural activity—rather than oscillatory synchrony—best distinguishes the state from ordinary waking consciousness. In a single highly experienced meditator (over 20,000 hours of practice) studied across 29 sessions, EEG recordings showed that combining subjective ratings of attention with a nonlinear connectivity metric improved the ability to decode the meditative state compared to using neural measures alone. Deeper jhana states were marked by a balance between feedback and feedforward neural processes, indicating an equalization of internally and externally directed information processing. These findings suggest that refined conscious states involve distinct large-scale neural dynamics not captured by traditional oscillatory measures.
Mindfulness (N Y)
September 26, 2025
Saampras Ganesan, Nicholas T. Van Dam, Sunjeev K. Kamboj et al.
3 citations
A 7-Tesla MRI study found that neurofeedback training (NFT) helps people become more aware of their mental states and boosts emotional well-being during real-world meditation. Participants who received NFT showed improved self-awareness and greater emotional benefits from meditation compared to those who did not receive NFT. The results suggest that NFT can enhance the positive effects of meditation practice.
bioRxiv Preprint Server
September 19, 2025
Kenneth Shinozuka, Winson F.z. Yang, Ruby M. Potash et al.
3 citations
preprint
Advanced meditators can enter a state called extended cessation (EC) in which they intentionally suppress consciousness and later emerge with clarity and equanimity. In the first electrophysiological study of EC, five meditators were recorded with EEG and MEG. EC markedly reduced alpha power and tended to increase neural complexity, unlike sleep, anesthesia, or disorders of consciousness. The findings indicate that the neural correlates of EC are distinct from other unconscious states and that complexity alone is not sufficient for consciousness, offering new insights into advanced meditation and human flourishing.
bioRxiv (Cold Spring Harbor Laboratory)
October 26, 2024
Saampras Ganesan, Nicholas T. van Dam, Sunjeev K. Kamboj et al.
3 citations
preprint
Personalized high-precision neurofeedback (NF) can help novice meditators better disengage from mental activity during meditation, improving emotional well-being and mindful awareness. In a single-blind, controlled study, 40 novices received two days of meditation training with feedback from either their own or a matched participant's posterior cingulate cortex (PCC) activity, measured using 7 Tesla fMRI. The experimental group showed stronger functional decoupling of PCC from dorsolateral prefrontal cortex, indicating improved control over disengagement. This led to greater improvements in emotional well-being and mindful awareness during a week of real-world self-guided meditation, supporting the utility of NF-guided meditation training.
Progress in Neuro-Psychopharmacology and Biological Psychiatry
February 27, 2026
Chris H. Miller, Angela Hickman, Caitlin Baten et al.
2 citations
Ketamine, originally developed as an anesthetic, has emerged as a novel treatment for major depressive disorder (MDD) and treatment-resistant depression (TRD). Its antidepressant properties were discovered serendipitously, leading to FDA approval for TRD and MDD with suicidal ideation. The drug acts primarily as an NMDA receptor antagonist, triggering a paradoxical AMPA-mediated glutamate surge that promotes synaptogenesis and neuroplasticity. Intravenous ketamine and intranasal esketamine differ in dosing, bioavailability, and onset. Common adverse effects include dissociation, sedation, and hypertension. Efficacy studies show mixed-to-positive results, with non-inferiority to established treatments like electroconvulsive therapy. Future research aims to develop predictive markers for personalized medicine.
Neuroscience and biobehavioral reviews
February 1, 2026
Jonathan M. Lieberman, Matthew D. Sacchet
2 citations
Advanced meditation, cultivated through long-term expertise, provides a unique experimental window into the core mechanisms of consciousness. Two classes of meditative phenomena are highlighted: advanced concentrative absorption (related to jhāna), where highly abstract awareness persists while typical features of consciousness fade, and meditative endpoints (related to nirodha), involving a temporary suspension of consciousness. These states serve as precise, replicable anchors for a minimal model framework that aims to identify the simplest possible form of conscious experience. Integrating advanced meditation into neuroscience offers a promising path toward isolating the neural mechanisms supporting consciousness in its most reduced and fundamental forms.
October 16, 2025
Sebastian Ehmann, Terje Sparby, Daniel M. Ingram et al.
2 citations
preprint
The analogy that meditation is like mental training is widely used but conceptually underdeveloped. This paper bridges that gap by introducing principles from exercise science—such as programming, periodization, and core training variables (volume, frequency, duration, density, intensity)—to contemplative training contexts. It proposes defining training intensity as the graded phenomenal presence of specific meditative qualities alongside minimization of counteractive qualities, referenced against a normative standard. Advanced meditation involves not just accumulating training volume but refining skills to access advanced states, stages, and endpoints. The authors argue that adopting a unified semantic framework and systematically assessing these variables would enable more precise, comparable, and cumulative analyses across studies.
February 6, 2025
Rosalind McAlpine, Merve Utanğaç, Joanna Kuć et al.
2 citations
preprint
Experienced meditators who also use psychedelics expect meditation to enhance acceptance and present-moment focus during psychedelic sessions, while increasing feelings of oceanic boundlessness and reducing anxious ego-dissolution. Among those with limited meditation experience (1-3 years) and few psychedelic sessions (1-20), adhering to a specific meditation tradition was linked to higher perceived benefits of meditation for psychedelic preparation. However, for highly experienced meditators (10+ years) with limited psychedelic use, non-adherents reported higher perceived benefits. Loving-Kindness Meditation was rated the most beneficial preparatory practice. Participants recommended about three weeks of daily 30-minute sessions, favoring online and asynchronous delivery.
October 28, 2024
Sebastian Ehmann, Idil Sezer, Isaac N. Treves et al.
2 citations
preprint
Long-term meditators show a distinct pattern of cognitive and brain changes, including enhanced integration of sensory and cognitive processes, reduced emotional reactivity, more rational decision-making, and altered self-awareness. Neuroimaging reveals increased activity in brain networks related to interoception and pain, along with reduced connectivity between executive and salience networks, decreased amygdala response to fear, and changes in default-mode network activity linked to emotional neutrality and non-ordinary states of consciousness. Methodological limitations, such as varied meditation practices among participants, prevent clear conclusions about specific cognitive changes over time. A unified research framework is needed to systematically study advanced meditation's unfolding stages and endpoints.
April 8, 2024
Saampras Ganesan, Aki Tsuchiyagaito, Greg J. Siegle et al.
2 citations
preprint
Meditation practices, which have been adapted into manualized interventions for conditions like depression, pain, addiction, and anxiety, show therapeutic promise, but their neuroscientific basis remains unclear. Current neuroimaging studies rely on small, heterogeneous datasets that vary in practice types, participant experience, clinical targets, and imaging methods, limiting generalizability and replicability. To address this, the ENIGMA-Meditation consortium was formed as a global collaboration to conduct systematic meta- and mega-analyses of distributed neuroimaging data using standardized methods. This framework aims to improve statistical power and rigorously characterize the neural mechanisms underlying meditation's effects on psychological and cognitive attributes, advancing the field of contemplative neuroscience.
May 29, 2019
Michael Lifshitz, Matthew D. Sacchet, Julia M. Huntenburg et al.
1 citation
Major depressive disorder involves abnormal communication between large-scale brain networks. A randomized, active-controlled trial tested whether mindfulness-based therapy could alter resting-state functional connectivity in clinically depressed patients. A brief, clinically effective mindfulness intervention functionally decoupled top-down control regions from brain areas involved in sensory, affective, and attentional processing. These findings identify specific neural targets of mindfulness training, offering new insight into how this therapeutic approach works.
bioRxiv Preprint Server
February 10, 2026
David Zarka, Winson F.z. Yang, Abel Rassat et al.
preprint
Extended cessation (EC) is a rare meditative state in which conscious experience temporarily stops, followed by heightened perception and emotional balance. In five highly trained meditators, electroencephalographic microstate analysis revealed that EC altered brain activity patterns linked to self-referential processing. Specifically, microstate B occurred less often and for shorter durations, while microstate C occurred more often and for longer durations. Transition probabilities also shifted, with more transitions from A and B to C and fewer from A to B. These changes appeared across delta, theta, and beta frequency bands, with additional band-specific effects for microstates A and D. The findings suggest EC involves a reweighting of self-referential and sensory processes.
Imaging Neuroscience
January 1, 2026
Hagar Tal, Winson F. Z. Yang, Matthew D. Sacchet
Neurofeedback (NF) has been proposed as a tool to support meditation practice, but a systematic review mapping the field across clinical and non-clinical contexts reveals that most studies are proof-of-concept and vary widely in design, implementation, and outcome measures. While NF consistently modulates neural activity, evidence for corresponding improvements in behavior, phenomenology, or transferable meditative skills remains limited. The review concludes that additional research is essential to determine whether NF can help practitioners overcome common meditative barriers, such as anxiety and self-doubt, and accelerate meditative development from novice to advanced meditators.