Neurosci Biobehav Rev
February 22, 2022
Idil Sezer, Diego A. Pizzagalli, Matthew D. Sacchet
206 citations
This review synthesizes evidence on the relationship between resting-state fMRI functional connectivity and mindfulness in both clinical and non-clinical populations. The authors find that mindfulness practice is associated with altered functional connectivity in brain networks involved in attention, self-referential processing, and emotion regulation. These changes may underlie the psychological benefits of mindfulness, but the review notes that the current evidence is mixed and limited by heterogeneous methodologies and small sample sizes.
Neurosci Biobehav Rev
January 14, 2025
Sofia Tzioridou, Teresa Campillo-Ferrer, Jorge Cañas-Martín et al.
5 citations
Lucid dreaming, where the dreamer becomes aware of being in a dream and often gains control over it, can occur spontaneously or be induced by behavioral, cognitive, or technological methods. This review examines evidence linking lucid dreaming to conditions such as nightmare disorder, depression, anxiety, psychosis, and dissociative states, and discusses possible neurobiological bases for these associations. It also explores contemplative sleep practices like Dream/Sleep Yoga and Yoga Nidrâ that train lucid states during sleep. Potential drawbacks of lucid dreaming interventions are outlined, along with impacts on individuals without clinical conditions, contributing to understanding its therapeutic possibilities and implications.
Neurosci Biobehav Rev
June 7, 2026
Yoav Domany, Aviv Solomon-Shashua
Suicidality, driven by unbearable psychological pain, is a uniquely human experience increasingly recognized as partly separable from depression in neurobiology and treatment response. Ketamine produces rapid reductions in suicidal ideation that precede and are partly separable from its antidepressant effects. The proposed Unified Rescue-Repair Model describes a two-phase mechanism: an acute rescue phase within minutes involving glutamatergic surge silencing the lateral habenula and disrupting network connectivity, and a structural repair phase unfolding over hours to days involving adenosine surge restoring neuronal bioenergetics and driving synaptogenesis. The model identifies two candidate phenotypes and proposes three predictions for validation.