Journal of cognitive neuroscience
November 1, 2024
Isaac N Treves, Kannammai Pichappan, Jude Hammoud et al.
35 citations
Greater trait mindfulness, measured by self-report scales, is consistently linked with reduced amygdala reactivity to emotional stimuli, increased cortical thickness in frontal and insular regions, and decreased connectivity within the default-mode network, converging with findings from intervention studies and mindfulness experts. However, associations with EEG metrics and between-network resting-state fMRI remain inconclusive. The authors recommend larger samples, multivariate approaches, and careful reliability testing, urging a move away from simplistic explanations of mindfulness and brain function.
Imaging neuroscience (Cambridge, Mass.)
January 1, 2025
Sebastian Ehmann, Idil Sezer, Isaac N Treves et al.
9 citations
Long-term meditators show a distinct pattern of cognitive and neural changes from prolonged mindfulness practice, including enhanced sensory integration, reduced negative emotional responses to pain, more rational decision-making, and altered self-awareness. Neuroimaging reveals increased activation in brain networks linked to interoception and pain (salience network), reduced connectivity between executive and salience networks, diminished fear and amygdala activation, and altered default-mode network activity associated with emotional neutrality and non-ordinary states of consciousness. Methodological limitations prevent firm conclusions about lasting trait effects, and a unified neurophenomenological framework is needed to systematically study advanced meditation's states and stages.
NeuroImage
November 19, 2025
Sebastian Ehmann, Idil Sezer, Arielle S Keller et al.
2 citations
Attention regulation is a core mechanism of mindfulness meditation. Long-term meditation enhances trait-level improvements in executive attention, sustained attention, orienting, and reduces the attentional blink. Preliminary evidence also shows improvements in response inhibition, alertness, and less mind-wandering. Alertness benefits most from long-term and intensive practice. Attention-based techniques outperform non-attention-based ones, while observe-and-release techniques aid orienting and detection of closely spaced stimuli. These findings suggest that meditation enhances attention according to training specificity, but meditative development is non-linear and multidimensional, requiring balanced cultivation of multiple faculties. Methodological limitations, such as heterogeneous designs and insufficient state-trait differentiation, complicate interpretations.
October 16, 2025
Sebastian Ehmann, Terje Sparby, Daniel M. Ingram et al.
2 citations
preprint
The analogy that meditation is like mental training is widely used but conceptually underdeveloped. This paper bridges that gap by introducing principles from exercise science—such as programming, periodization, and core training variables (volume, frequency, duration, density, intensity)—to contemplative training contexts. It proposes defining training intensity as the graded phenomenal presence of specific meditative qualities alongside minimization of counteractive qualities, referenced against a normative standard. Advanced meditation involves not just accumulating training volume but refining skills to access advanced states, stages, and endpoints. The authors argue that adopting a unified semantic framework and systematically assessing these variables would enable more precise, comparable, and cumulative analyses across studies.
October 28, 2024
Sebastian Ehmann, Idil Sezer, Isaac N. Treves et al.
2 citations
preprint
Long-term meditators show a distinct pattern of cognitive and brain changes, including enhanced integration of sensory and cognitive processes, reduced emotional reactivity, more rational decision-making, and altered self-awareness. Neuroimaging reveals increased activity in brain networks related to interoception and pain, along with reduced connectivity between executive and salience networks, decreased amygdala response to fear, and changes in default-mode network activity linked to emotional neutrality and non-ordinary states of consciousness. Methodological limitations, such as varied meditation practices among participants, prevent clear conclusions about specific cognitive changes over time. A unified research framework is needed to systematically study advanced meditation's unfolding stages and endpoints.
Mindfulness
November 19, 2025
Sebastian Ehmann, Ryan T. Pohlig, Alejandro Chaoul et al.
1 citation
A 9-month online program teaching traditional Tibetan Mind-Body meditation practices based on Bon Dzogchen philosophy led to gradual improvements in compassion for self and others, mindfulness, flourishing, and non-dual awareness among 30 predominantly experienced meditators. Improvements were independent of how often participants meditated, suggesting the program's structure itself drove benefits. The findings provide preliminary evidence that such practices may foster advanced meditative states tied to self-transcendence. Limitations include the small, self-selected sample, lack of a control group, and reliance on quantitative measures, which may miss the richness of advanced meditative experiences.
Addictive behaviors
June 1, 2026
Sebastian Ehmann, Nathan M Hager, Paul S Regier et al.
Using data from the 2023 U.S. National Survey on Drug Use and Health, lifetime use of mescaline or peyote was associated with lower opioid use disorder severity, while lifetime use of LSD, psilocybin, MDMA, or DMT was associated with higher severity. The link between mescaline/peyote use and lower severity appeared only among adults with high mental health impairment. The findings suggest that different types of psychedelic use have divergent relationships with opioid use disorder severity, and that mental health status may influence these associations.
PsyArXiv
May 27, 2026
Asiya Gul, Sebastian Ehmann, Catherine Prueitt et al.
preprint
This theoretical paper proposes extending the scientific study of advanced meditation to Sufism within Islam, comparing self-attenuation practices across Theravāda Buddhism, Tibetan Dzogchen, and Sufi traditions. The authors argue that contemplative traditions beyond Buddhism, particularly Sufism, offer valuable but underexplored models for understanding advanced meditative states and their effects on self-related processing. By examining similarities and differences in how these traditions conceptualize and cultivate self-transcendence, the paper suggests that a broader cross-traditional framework can enrich scientific understanding of meditation's transformative potential. The analysis highlights common themes of self-diminishment and non-dual awareness while respecting each tradition's unique doctrinal and practical contexts.
PsyArXiv
December 31, 2025
Sebastian Ehmann, Nikoloz Mosahvili, Angela White et al.
preprint
People with higher levels of dispositional mindfulness—the tendency to pay attention to present-moment experience nonjudgmentally—are more likely to experience self-transcendent perceptual changes during a naturalistic psychedelic retreat. Over a prospective longitudinal observational study, participants who scored higher on mindfulness measures reported greater alterations in consciousness, including feelings of unity and sacredness. The findings suggest that pre-existing mindfulness may shape how individuals respond to psychedelic experiences, potentially enhancing their capacity for profound shifts in perception and self-awareness.
December 9, 2025
Sebastian Ehmann, Terje Sparby, Vanessa Naughton et al.
preprint
Advanced meditators report profound psychological changes across emotional, cognitive, interpersonal, and existential domains, including vast improvements in baseline well-being, consistently strong positive attitudes, increased positive affect, enhanced mental clarity and attentional stability, positive shifts in life orientation, and transformative changes in mental health conditions. Many described existential insights arising through resolving psychological difficulties, leading to reduced suffering and deeper meaning. Additional themes included synergistic effects between meditation, psychotherapy, and psychedelics. This provides initial empirical evidence that advanced meditation supports profound psychological transformation and reduced suffering.
PsyArXiv
November 2, 2025
Sebastian Ehmann, Nathan M. Hager, Paul S. Regier et al.
preprint
Among a national sample of US adults, lifetime psychedelic use is associated with lower severity of opioid use disorder, but this relationship depends on broader substance-use patterns and mental health. The protective association appears specific to certain substance-use profiles and is mediated by mental health status. The findings suggest that psychedelic use alone does not uniformly reduce opioid use disorder severity; rather, the context of other substance use and psychological well-being shapes the association.
October 8, 2025
Sebastian Ehmann, Brian Lord, Erica Cook et al.
preprint
Inhibiting the posterior cingulate cortex with transcranial focused ultrasound during a ten-day silent retreat enhanced meditative qualities such as equanimity, concentration, and sensory clarity. Twenty-eight meditators received two stimulation sessions and reported significant increases in trait mindfulness, nondual awareness, and interoceptive body listening. Qualitative reports showed consistent differences between stimulation and non-stimulation days, including shifts in self-perception and cathartic emotional release. The effects often interacted with participants' ongoing psychological challenges, suggesting tFUS may increase baseline equanimity and support meditative development. Implementation was feasible but required logistical planning; limitations include the quasi-experimental design and reliance on self-reports.