NMDA receptor function in large-scale anticorrelated neural systems with implications for cognition and schizophrenia
Proceedings of the National Academy of Sciences September 25, 2012 Alan Anticevic, Mark G. Gancsos, John D. Murray et al. 260 citations
Glutamate signaling through NMDA receptors is essential for brain computations that support cognition, and its disruption may contribute to schizophrenia. Using ketamine, an NMDA receptor antagonist, the study found that the normal anticorrelation between the default-mode and task-positive brain systems was disrupted during a working memory task. The degree of this disruption predicted task performance and produced schizophrenia-like symptoms. A computational model suggests that cortical disinhibition underlies this effect, linking glutamate's role in large-scale brain organization to cognition and psychiatric symptoms.