Effects of mesyl salvinorin B alone and in combination with naltrexone on alcohol deprivation effect in male and female mice.
Neuroscience letters April 23, 2018 Yan Zhou, Rachel Crowley, Thomas Prisinzano et al.
A single injection of the kappa opioid receptor agonist Mesyl Salvinorin B (MSB) at 3 mg/kg prevented the alcohol deprivation effect—a model of relapse—in both male and female mice that had developed excessive alcohol intake. A lower dose combination of MSB (0.3 mg/kg) with naltrexone (1 mg/kg) also reduced the effect, suggesting synergy. MSB alone or combined with naltrexone shows potential for treating alcohol relapse.