Piotr Wlaź

Salvinorin A Does Not Affect Seizure Threshold in Mice

Molecules March 7, 2020 Katarzyna Socała, Urszula Doboszewska, Piotr Wlaź

Salvinorin A, a potent plant-derived hallucinogen that selectively activates the κ-opioid receptor, did not alter seizure thresholds in mice across three acute seizure tests. At doses of 0.1–10 mg/kg injected intraperitoneally, it had no significant effect on the thresholds for myoclonic twitch, generalized clonic seizure, forelimb tonus, tonic hindlimb extension, or psychomotor seizures. It also did not impair motor coordination or muscular strength. This preliminary report suggests that salvinorin A does not influence seizure susceptibility in these models, though further research is needed.