Effect of cannabinol, tetrahydrocannabivarin and cannabidiol on voluntary alcohol consumption.
Alcohol and alcoholism (Oxford, Oxfordshire) March 17, 2026 Ieva Poceviciute, Martynas Arbaciauskas, Rokas Buisas et al.
Three non-psychoactive phytocannabinoids—cannabinol (CBN), tetrahydrocannabivarin (THCV), and cannabidiol (CBD)—all reduced voluntary alcohol consumption in male Wistar rats that had been drinking alcohol long-term. CBN and THCV lowered alcohol intake and preference with mild sedation; CBD had a minor effect on consumption, did not affect preference, reduced activity, and lowered positive emotional states. None caused discomfort or distress. CBN and THCV may be promising for treating alcohol use disorder.