Psychedelics and the Human Receptorome
PLoS ONE January 1, 2010 Olivier Jacques Manzoni, Thomas S. Ray 295 citations
Psychedelic drugs are known to produce their mental effects primarily by activating 5-HT2A and 5-HT2C serotonin receptors. This reference work presents new data on the binding affinity of twenty-five psychedelic drugs at fifty-one receptors, transporters, and ion channels, along with literature data on ten additional drugs. A new method normalizes affinity data to allow direct comparison across drugs. The findings show that psychedelic drugs, particularly phenylalkylamines, are not as selective as commonly thought, interacting with forty-two of forty-nine broadly tested sites. The thirty-five drugs display diverse interaction patterns across eighteen different receptors, suggesting that this diversity may underlie the qualitative differences in their subjective effects.